What an honor that a high-ranking tribal leader asks the player characters to escort his daughter as she travels to meet her fiancé. What a pain in the ass that the woman is a raging harpy. The gang has a long road trip to suffer through, until they stop for gas and get jumped by a shitkicker Black Spiral Dancer and his two nasty Kin brothers. They're pretty sad and weak as Spirals go; the characters can probably whip them real good. But before the victory is complete, the Dancer throws a Kiss of the Wyrm dart (see Freak Legion) at Daddy Ahroun's little darling...and suddenly she's a seething pillar of fomori terror. Sure, the characters can (gladly) bonk her on the head to keep her quiet, but who's going to heal her? Curing the poison requires a Rite of Purification. The Kin would be idiots to show up at the wedding (only two days hence) and ask for help! They're going to need assistance from another quarter.
Perhaps the Kin have heard of mages and their vast powers; their desperate search could turn the session into an interesting crossover with Mage: The Ascension. Maybe one of the characters knows of a Ronin, and prehaps the outcast is familiar with the Rite of Purification. The characters may want to resort to werewolves outside their tribe, even though the price for assistance and silence might be heavy.
In any case, they're fighting the clock in more ways than one. Should they fail to deliver the bride healthy and on time, her father (and probably the rest of her tribe) will hurt the poor group.